Plaintiffs of the first two Xarelto bellwether cases have now decided to approach the United States Court of Appeals for the Fifth Circuit presenting appeals to overturn the verdicts of their cases. This decision followed Judge Fallon's decision of denying new trials to both the plaintiffs in September. Their trials were a part of the 18,000+ lawsuits filed in the U.S. District Court, Eastern District of Louisiana MDL 2592 with additional cases filed in the federal and state courts across the country. Both appeals have a few common and individual facts. The defendants' stand regarding the safety and efficacy of Xarelto stays, stating that Xarelto's FDA-approved label contains accurate, science-based information on the benefits and risks of this life-saving medicine.